5 CONCLUSION
The findings presented in the meta-analysis have important implications
worldwide, as many countries still struggle with COVID-19, and hotspots
put children at risk for infection. More research into the
pathophysiology of multisystem inflammatory syndrome is needed to
understand how it differs from that of Kawasaki disease. It could also
begin to provide an idea of why some children experience shock and
hypotension, while others have less acute complications. Also, a
comparison of relative rates of coronary artery aneurysms in multisystem
inflammatory syndrome versus Kawasaki disease would help medical
decision making.
Although multisystem inflammatory syndrome still appears to be a rare
occurrence in COVID-19 positive children, it has become clear that the
Kawasaki-like disease requires aggressive medical management with a
multidisciplinary team and close, long-term follow up. Recognizing the
atypical presentation of the multisystem inflammatory syndrome,
monitoring patients for cardiac and renal decompensation, and early
interventions to treat the exaggerated immune response in these patients
is critical to prevent further morbidity.