Data Source
Data was sourced from the European Anaphylaxis Registry, a database that
collects data regarding anaphylactic reactions from 137 specialized
tertiary allergy centres in ten European countries (Germany, Austria,
Switzerland, Poland, Italy, Spain, Ireland, Greece, France, Bulgaria),
and Brazil. Data collection is based on an online questionnaire which
continuously developed over time to include additional information,
mainly focused on elicitor(s), symptoms, course of reaction, co-factors,
emergency treatment, diagnostic procedures and preventive/long-term
management (current version 8.0).
Pseudo-anonymized data of patients with anaphylaxis were reported, after
in-depth review of the anaphylaxis cases by trained health care
professionals from a tertiary allergy centre. On their first visit in
the centre parents were asked to provide written informed consent to
allow registration of the child’s medical history and reaction details
in the database after completion of the diagnostic workup.
Ethical approval was obtained from the Ethics Committee, Charité -
Universitätsmedizin Berlin, Germany (the coordinating centre), as well
as from the local Ethic Committees in all participating centres.