Maternal Anxiety and Infants Birth weight and Length of Gestation. A
sibling design.
Abstract
Objective: To examine the effect of prenatal maternal anxiety on
birthweight and preterm birth, controlling for genetic confounding using
a sibling comparison design. Design: This is a population-based
prospective cohort study with a comparison of a population level
analysis and a sibling analysis. Setting: This study is based on the
Norwegian Mother, Father and Child Cohort Study (MoBa) conducted by the
Norwegian Institute of Public Health
(https://www.fhi.no/en/studies/moba/ ). Sample: Women and their chiold
participating in the MoBa (n= 78,117) and women participating with more
than one pregnancy (n=12,480). Methods: Associations between prenatal
maternal anxiety (measured across the 17th and 30th weeks) and birth
outcomes (birthweight and gestational age) were examined using linear
regression with adjustment for family-shared confounding in a sibling
comparison design. Main outcomes: Birthweight (in grams) and gestational
age (ultrasound measure in days) were obtained from the Medical Birth
Registry of Norway. Results: The maternal anxiety score during pregnancy
was inversely associated with newborn’s birthweight (Beta = -112,8 95%
CI: –142.7, -83.0) and gestational age (Beta=-1.77, 95% CI: -2.42,
-1.13) after adjustment for several covariates. The association of the
maternal anxiety score with both newborn’s birthweight (Beta=-173.9,
95% CI: -252.3, -95.4) and gestational age (Beta=-1.08, 95% CI: -2.91,
-0.75) remained but was largely weakened after further adjusting for the
shared-family confounding in the sibling comparison design. Conclusion:
The link between maternal prenatal anxiety and birthweight and
gestational age remained after adjusting for shared family confounding,
yet estimates were weakened after adjusting for environmental
covariates.