Results
The odds ratio of hyperthyroidism among PE patients compared with control subjects was 2.0 (0.6-6.9 at 95% CI, p=.03). The odds ratio of PE among hyperthyroid patients compared with euthyroid subjects was 2.2 (1.1-4.5 at 95% CI, p=.0001). The odds ratio of PE among hyperthyroid patients compared with hypothyroid subjects was 13.2 (5.6-31.4 at 95% CI, p=.006). The odds ratio of DE among hypothyroid patients compared with hyperthyroid subjects was 57.4 (16.9-194.5 at 95% CI, p=.0001). Table-3 summarizes the findings from interventional studies.
The standardized mean serum TSH difference between PE and non-PE subjects in the random-effects model had an estimate of effect of -0.45 (lower and upper bound: -0.91 and 0.006; SE: 0.23; p=0.05) (Figure 2.A). The effect of treatment of hyperthyroidism on mean IELT in the random-effects model was as an overall estimate of effect of 0.64 (lower and upper bound: 0.27 and 1.02; SE: 0.19; p<0.001) (Figure 2.B). The effect of treatment of hyperthyroidism on the prevalence of PE in the binary random-effects model was as an overall estimate of effect of 0.13 (lower and upper bound: 0.05 and 0.33; p<0.001) (Figure 2.C).