Gene-environment interactions
Interaction effects between the GRS and environmental exposures were investigated using a multiple regression model with an interaction term. This analysis used GRS classified as high, moderate, and low in addition to pre- and post-natal exposure to cigarette smoke, pets (dog, cat, furry, and non-furry animals), nitrogen dioxide, and breastfeeding duration. Sex and the first three PCs were included as covariates in the model.