REFERENCES
1. Sham P, Bishop DT. Analysis of multifactorial disease . Bios 2000
2. Duffy DL, Martin NG, Battistutta D, Hopper JL, Mathews JD. Genetics of asthma and hay fever in Australian twins. Am Rev Respir Dis1990;142 :1351–1358.
3. Thomsen SF, Ulrik CS, Kyvik KO, Ferreira MAR, Backer V. Multivariate genetic analysis of atopy phenotypes in a selected sample of twins.Clin Exp Allergy 2006;36 :1382–1390.
4. Neville MDC, Choi J, Lieberman J, Duan QL. Identification of deleterious and regulatory genomic variations in known asthma loci.Respir Res Published Online First: 2018. doi:10.1186/s12931-018-0953-2
5. Vicente CT, Revez JA, Ferreira MAR. Lessons from ten years of genome-wide association studies of asthma. Clin Transl Immunol2017;6 :e165.
6. Belsky DW, Sears MR, Hancox RJ, Harrington HL, Houts R, Moffitt TE et al. Polygenic risk and the development and course of asthma: An analysis of data from a four-decade longitudinal study. Lancet Respir MedPublished Online First: 2013. doi:10.1016/S2213-2600(13)70101-2
7. Torkamani A, Wineinger NE, Topol EJ. The personal and clinical utility of polygenic risk scores. Nat. Rev. Genet. 2018. doi:10.1038/s41576-018-0018-x
8. Chatterjee N, Shi J, García-Closas M. Developing and evaluating polygenic risk prediction models for stratified disease prevention. Nat. Rev. Genet. 2016. doi:10.1038/nrg.2016.27
9. Morales E, Duffy D. Genetics and Gene-Environment Interactions in Childhood and Adult Onset Asthma. Front. Pediatr. 2019. doi:10.3389/fped.2019.00499
10. Moffatt MF, Kabesch M, Liang L, Dixon AL, Strachan D, Heath S et al. Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature Published Online First: 2007. doi:10.1038/nature06014
11. Bisgaard H, Bønnelykke K, Sleiman PMA, Brasholt M, Chawes B, Kreiner-Møller E et al. Chromosome 17q21 gene variants are associated with asthma and exacerbations but not atopy in early childhood. Am J Respir Crit Care Med Published Online First: 2009. doi:10.1164/rccm.200809-1436OC
12. Granell R, Henderson AJ, Timpson N, St. Pourcain B, Kemp JP, Ring SM et al. Examination of the relationship between variation at 17q21 and childhood wheeze phenotypes. J Allergy Clin Immunol Published Online First: 2013. doi:10.1016/j.jaci.2012.09.021
13. Bønnelykke K, Ober C. Leveraging gene-environment interactions and endotypes for asthma gene discovery. J. Allergy Clin. Immunol. 2016. doi:10.1016/j.jaci.2016.01.006
14. Dizier MH, Bouzigon E, Guilloud-Bataille M, Siroux V, Lemainque A, Boland A et al. Evidence for gene × smoking exposure interactions in a genome-wide linkage screen of asthma and bronchial hyper-responsiveness in EGEA families. Eur J Hum Genet Published Online First: 2007. doi:10.1038/sj.ejhg.5201830
15. Pividori M, Schoettler N, Nicolae DL, Ober C, Im HK. Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies. Lancet Respir Med Published Online First: 2019. doi:10.1016/S2213-2600(19)30055-4
16. Carr TF, Bleecker E. Asthma heterogeneity and severity. World Allergy Organ. J. 2016. doi:10.1186/s40413-016-0131-2
17. Ducharme FM, Dell SD, Radhakrishnan D, Grad RM, Watson WTA, Yang CL et al. Diagnosis and management of asthma in preschoolers: A Canadian Thoracic Society and Canadian Paediatric Society position paper.Can Respir J Published Online First: 2015. doi:10.1155/2015/101572
18. Sears MR, Greene JM, Willan AR, Wiecek EM, Taylor DR, Flannery EM et al. A longitudinal, population-based, cohort study of childhood asthma followed to adulthood. N Engl J Med 2003;349 :1414–1422.
19. Subbarao P, Anand SS, Becker AB, Befus AD, Brauer M, Brook JR et al. The Canadian Healthy Infant Longitudinal Development (CHILD) Study: examining developmental origins of allergy and asthma. Thorax2015;70 :998–1000.
20. Takaro TK, Scott JA, Allen RW, Anand SS, Becker AB, Befus AD et al. The Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort study: assessment of environmental exposures. J Expo Sci Environ Epidemiol 2015;25 :580–592.
21. Moraes TJ, Lefebvre DL, Chooniedass R, Becker AB, Brook JR, Denburg J et al. The canadian healthy infant longitudinal development birth cohort study: Biological samples and biobanking. Paediatr Perinat Epidemiol Published Online First: 2015. doi:10.1111/ppe.12161
22. Sbihi H, Allen RW, Becker A, Brook JR, Mandhane P, Scott JA et al. Perinatal Exposure to Traffic-Related Air Pollution and Atopy at 1 Year of Age in a Multi-Center Canadian Birth Cohort Study. Environ Health Perspect Published Online First: 2015. doi:10.1289/ehp.1408700
23. Chang CC, Chow CC, Tellier LC, Vattikuti S, Purcell SM, Lee JJ. Second-generation PLINK: rising to the challenge of larger and richer datasets. Gigascience Published Online First: 2015. doi:10.1186/s13742-015-0047-8
24. Das S, Forer L, Schönherr S, Sidore C, Locke AE, Kwong A et al. Next-generation genotype imputation service and methods. Nat Genet Published Online First: 2016. doi:10.1038/ng.3656
25. Delaneau O, Coulonges C, Zagury JF. Shape-IT: New rapid and accurate algorithm for haplotype inference. BMC Bioinformatics Published Online First: 2008. doi:10.1186/1471-2105-9-540
26. Fuchsberger C, Abecasis GR, Hinds DA. minimac2: faster genotype imputation. Bioinformatics 2014;31 :782–784.
27. McCarthy S, Das S, Kretzschmar W, Delaneau O, Wood AR, Teumer A et al. A reference panel of 64,976 haplotypes for genotype imputation.Nat Genet Published Online First: 2016. doi:10.1038/ng.3643
28. Price AL, Patterson NJ, Plenge RM, Weinblatt ME, Shadick NA, Reich D. Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet Published Online First: 2006. doi:10.1038/ng1847
29. Auton A, Abecasis GR, Altshuler DM, Durbin RM, Bentley DR, Chakravarti A et al. A global reference for human genetic variation. Nature. 2015. doi:10.1038/nature15393
30. Machiela MJ, Chanock SJ. LDlink: A web-based application for exploring population-specific haplotype structure and linking correlated alleles of possible functional variants. Bioinformatics Published Online First: 2015. doi:10.1093/bioinformatics/btv402
31. D. Turner S. qqman: an R package for visualizing GWAS results using Q-Q and manhattan plots. J Open Source Softw Published Online First: 2018. doi:10.1101/005165
32. Choi SW, Mak TSH, O’Reilly PF. A guide to performing Polygenic Risk Score analyses. bioRxiv Published Online First: 2018. doi:10.1101/416545
33. McLaren W, Gil L, Hunt SE, Riat HS, Ritchie GRS, Thormann A et al. The Ensembl Variant Effect Predictor. Genome Biol Published Online First: 2016. doi:10.1186/s13059-016-0974-4
34. Boyle AP, Hong EL, Hariharan M, Cheng Y, Schaub MA, Kasowski M et al. Annotation of functional variation in personal genomes using RegulomeDB. Genome Res 2012;22 :1790–1797.
35. The GteC. The Genotype-Tissue Expression (GTEx) project. Nat Genet 2013;45 :580–585.
36. Barbosa AM, Brown J., Jiménez-Valverde A, Real R. modEvA: Model Evaluation and Analysis. R Packag. version 0.5.2/r40. 2014.
37. Chao KL, Kulakova L, Herzberg O. Gene polymorphism linked to increased asthma and IBD risk alters gasdermin-B structure, a sulfatide and phosphoinositide binding protein. Proc Natl Acad Sci U S APublished Online First: 2017. doi:10.1073/pnas.1616783114
38. Caramori G, Lim S, Ito K, Tomita K, Oates T, Jazrawi E et al. Expression of GATA family of transcription factors in T-cells, monocytes and bronchial biopsies. Eur Respir J Published Online First: 2001. doi:10.1183/09031936.01.00040701
39. Li S, Wang Y, Zhang Y, Lu MM, DeMayo FJ, Dekker JD et al. Foxp1/4 control epithelial cell fate during lung development and regeneration through regulation of anterior gradient 2. Development2012;139 :2500–2509.
40. Toncheva AA, Potaczek DP, Schedel M, Gersting SW, Michel S, Krajnov N et al. Childhood asthma is associated with mutations and gene expression differences of ORMDL genes that can interact. Allergy Eur J Allergy Clin Immunol Published Online First: 2015. doi:10.1111/all.12652
41. Das S, Miller M, Broide DH. Chromosome 17q21 Genes ORMDL3 and GSDMB in Asthma and Immune Diseases. In: Advances in Immunology . 2017 doi:10.1016/bs.ai.2017.06.001
42. Azad MB, Vehling L, Lu Z, Dai D, Subbarao P, Becker AB et al. Breastfeeding, maternal asthma and wheezing in the first year of life: A longitudinal birth cohort study. Eur Respir J Published Online First: 2017. doi:10.1183/13993003.02019-2016
43. Emenius G, Pershagen G, Berglind N, Kwon HJ, Lewné M, Nordvall SL et al. NO 2 , as a marker of air pollution, and recurrent wheezing in children: A nested case-control study within the BAMSE birth cohort.Occup Environ Med Published Online First: 2003. doi:10.1136/oem.60.11.876