Supplemental Figure S6. Identification of the GRS associated with recurrent wheeze. This plot illustrates the process in determining the variants for inclusion in the GRS analysis. The y-axis is -log10 transformed p-value of the GRS and the x-axis shows the number of variants included in that GRS from the top associated 100 variants (results from previously published GWAS). The GRS with the lowest p-value occur with the inclusion of first (i.e. most strongly associated) 4 variants, which is indicated by the red colored bar (p=1e-7.8).