Study objective
This study was undertaken to characterize the outcomes and complications
of thrombolytic therapy for pediatric thrombosis at our tertiary care
center. We also sought to compare patient outcomes when different
interventional approaches were used: CDT via an indwelling venous
catheter versus bolus tPA administration “on-table” during a single
interventional procedure without subsequent catheter-directed tPA
infusion. Thrombolysis refers to the active administration of a
thrombolytic agent (in this case, tPA). Catheter-directed thrombolysis
involves the distribution of tPA through a multi-side hole infusion
catheter to allow systemic distribution of the agent at a controlled
rate over a length of time. Therefore, a patient who undergoes on-table
thrombolysis prior or after the initiation of CDT receives tPA. On-table
tPA is a bolus dose that is made into the area of thrombus and then
followed by other various intervention. The patients in this review did
not undergo post-procedural CDT.