Pharmacokinetic analyses
Pharmacokinetic parameters derived from serum sample concentrations were
calculated using a noncompartmental analysis (NCA). (NCA). The NCA was
performed using R version 3.5.3 (22) while the linear trapezoid rule was
used for the calculation of AUCs. Analysis of the differences between
methods were based on least squares means from the ANOVA of the
ln-transformed AUC0-t AUC0-inf, and
Cmax. In addition, Wilcoxons tests were performed on
Tmax.