Introduction:
DiGeorge syndrome is a primary immunodeficiency resulting from a microdeletion 22q11.2 and leads to a multifaceted disorder. This microdeletion results in abnormal development of third and fourth pharyngeal pouches. The presentation and clinical features vary from person to person and commonly include facial abnormalities, hypoparathyroidism, heart defects, thymic hypoplasia, immunodeficiency, and other clinical problems [1]. It is occasionally associated with cytopenias, including idiopathic thrombocytopenic purpura (ITP) and autoimmune hemolytic anemia (AIHA.) Usually, more than one cell line is affected by the patient experiencing cytopenias. We report a case of AIHA secondary to DiGeorge syndrome in an adult female, likely precipitated by a viral illness and vitamin B12 deficiency.
Keywords: DiGeorge Syndrome, Autoimmune hemolysis, AIHA, B12 deficiency, Viral illness.