Data Data Source Population Ancestry Sample size Exposure definition Adjustments
Genetic variants in or near IL-6R associated with variation in CRP CHARGE Inflammation Working Group13 European 204,402 Change in natural log transformed CRP (mg/L) per copy increment of the effect allele Age, sex, population structure. Estimates scaled for the effect of Tocilizumab (8 mg/kg) on CRP levels between 4 – 24 weeks after administration.
Blood urea nitrogen (BUN) Chronic Kidney Disease Genetics Consortium meta-analysis (n=33 studies)14 Trans-ancestry 416,178 Change in BUN per copy increment of effect allele Age, sex, population structure
Estimated glomerular filtration rate (eGFR) Chronic Kidney Disease Genetics Consortium meta-analysis (n=61 studies)14 Trans-ancestry 765,348 Change in log eGFR per copy increment of effect allele Age, sex, population structure
Chronic Kidney Disease Binary outcome eGFR > 60 ml min−1 per 1.73 m2.
Chronic Kidney Disease Genetics Consortium meta-analysis (n=30 studies)14
Trans-ancestry
64,164 cases 561,055 controls
Log odds ratio for CKD per copy increment of effect allele
Age, sex, population structure