Genetic variants in or near IL-6R associated with variation in
CRP |
CHARGE Inflammation Working Group13
|
European |
204,402 |
Change in natural log transformed CRP (mg/L) per copy
increment of the effect allele |
Age, sex, population structure.
Estimates scaled for the effect of Tocilizumab (8 mg/kg) on CRP levels
between 4 – 24 weeks after administration. |
Blood urea nitrogen (BUN) |
Chronic Kidney Disease Genetics
Consortium meta-analysis (n=33 studies)14
|
Trans-ancestry |
416,178 |
Change in BUN per copy increment of effect
allele |
Age, sex, population structure |
Estimated glomerular filtration rate (eGFR) |
Chronic Kidney
Disease Genetics Consortium meta-analysis (n=61
studies)14
|
Trans-ancestry |
765,348 |
Change in log
eGFR per copy increment of effect allele |
Age, sex, population
structure |
Chronic Kidney Disease
Binary outcome eGFR > 60 ml min−1 per
1.73 m2.
|
Chronic Kidney Disease Genetics Consortium meta-analysis (n=30
studies)14
|
Trans-ancestry
|
64,164 cases
561,055 controls
|
Log odds ratio for CKD per copy increment of effect allele
|
Age, sex, population structure
|