Forest plots showing the causal estimates for chronic kidney disease (CKD), log eGFR (estimated glomerular filtration rate) and blood urea nitrogen (BUN) with different meta-analysis methods (simple median, weighted median, inverse-variance weighted, MR-Egger). eGFR and BUN are presented as causal estimates with 95% confidence interval. CKD is described as the odds ratio (95% confidence interval) of having CKD given genetically proxied IL-6 signalling inhibition. Full results table described in appendix I.