References
1. Longenecker JC, Coresh J, Powe NR, Levey AS, Fink NE, Martin A, et al. Traditional cardiovascular disease risk factors in dialysis patients compared with the general population: the CHOICE Study. J Am Soc Nephrol [Internet]. 2002 Jul 1 [cited 2020 Sep 24];13(7):1918–27. Available from: http://www.ncbi.nlm.nih.gov/pubmed/10703676
2. Herzog CA, Asinger RW, Berger AK, Charytan DM, Díez J, Hart RG, et al. Cardiovascular disease in chronic kidney disease. A clinical update from Kidney Disease: Improving Global Outcomes (KDIGO). Kidney Int [Internet]. 2011 Sep 2 [cited 2020 Sep 24];80(6):572–86. Available from: https://www.sciencedirect.com/science/article/pii/S0085253815551053
3. Spoto B, Mattace-Raso F, Sijbrands E, Leonardis D, Testa A, Pisano A, et al. Association of IL-6 and a functional polymorphism in the IL-6 gene with cardiovascular events in patients with CKD. Clin J Am Soc Nephrol [Internet]. 2015 Feb 6 [cited 2020 Sep 24];10(2):232–40. Available from: http://www.ncbi.nlm.nih.gov/pubmed/25492254
4. Libby P, Ridker PM, Hansson GK. Inflammation in Atherosclerosis: From Pathophysiology to Practice. J Am Coll Cardiol [Internet]. 2009 Dec 1 [cited 2020 Sep 24];54(23):2129–38. Available from: https://www.sciencedirect.com/science/article/pii/S073510970903006X
5. Zoccali C, Mallamaci F, Tripepi G. Inflammatory proteins as predictors of cardiovascular disease in patients with end-stage renal disease. Nephrol Dial Transplant [Internet]. 2004 Aug 1 [cited 2020 Sep 24];19(suppl_5):v67–72. Available from: https://academic.oup.com/ndt/article-lookup/doi/10.1093/ndt/gfh1059
6. Bermudez EA, Rifai N, Buring J, Manson JE, Ridker PM. Interrelationships Among Circulating Interleukin-6, C-Reactive Protein, and Traditional Cardiovascular Risk Factors in Women. Arterioscler Thromb Vasc Biol [Internet]. 2002 Oct [cited 2020 Sep 24];22(10):1668–73. Available from: https://www.ahajournals.org/doi/10.1161/01.ATV.0000029781.31325.66
7. Honda H, Qureshi AR, Heimbürger O, Barany P, Wang K, Pecoits-Filho R, et al. Serum albumin, C-reactive protein, interleukin 6, and fetuin a as predictors of malnutrition, cardiovascular disease, and mortality in patients with ESRD. Am J Kidney Dis [Internet]. 2006 Jan [cited 2020 Sep 24];47(1):139–48. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16377395
8. Georgakis MK, Malik R, Gill D, Franceschini N, Sudlow CLM, Dichgans M, et al. Interleukin-6 Signaling Effects on Ischemic Stroke and Other Cardiovascular Outcomes: A Mendelian Randomization Study. Circ Genomic Precis Med [Internet]. 2020 Jun [cited 2020 Sep 24];13(3):e002872. Available from: https://www.ahajournals.org/doi/10.1161/CIRCGEN.119.002872
9. Ridker PM, Everett BM, Thuren T, MacFadyen JG, Chang WH, Ballantyne C, et al. Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease. N Engl J Med [Internet]. 2017 Sep 21 [cited 2020 Sep 24];377(12):1119–31. Available from: http://www.nejm.org/doi/10.1056/NEJMoa1707914
10. Kakkar R, Lo L, Kling D, Devalaraja M, Davidson M. Effects of Ziltivekimab (ZILTI), a Novel Anti-Interleukin-6 Monoclonal Antibody, on Markers of Inflammation and Cardiovascular Risk in Patients With Chronic Kidney Disease on Hemodialysis. Circulation. 2019;
11. Davies NM, Holmes M V, Davey Smith G. Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians. BMJ [Internet]. 2018 Jul 12 [cited 2020 Sep 24];362:k601. Available from: http://www.ncbi.nlm.nih.gov/pubmed/30002074
12. Walker VM, Davey Smith G, Davies NM, Martin RM. Mendelian randomization: a novel approach for the prediction of adverse drug events and drug repurposing opportunities. Int J Epidemiol [Internet]. 2017 [cited 2020 Sep 24];46(6):2078–89. Available from: http://www.ncbi.nlm.nih.gov/pubmed/29040597
13. Ligthart S, Vaez A, Võsa U, Stathopoulou MG, de Vries PS, Prins BP, et al. Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders. Am J Hum Genet [Internet]. 2018 Nov 1 [cited 2020 Sep 24];103(5):691–706. Available from: https://www.sciencedirect.com/science/article/pii/S0002929718303203
14. Wuttke M, Li Y, Li M, Sieber KB, Feitosa MF, Gorski M, et al. A catalog of genetic loci associated with kidney function from analyses of a million individuals. Nat Genet [Internet]. 2019 Jun [cited 2020 Sep 24];51(6):957–72. Available from: http://www.nature.com/articles/s41588-019-0407-x
15. Burgess S, Thompson SG. Interpreting findings from Mendelian randomization using the MR-Egger method. Eur J Epidemiol [Internet]. 2017 May 19 [cited 2020 Sep 24];32(5):377–89. Available from: http://link.springer.com/10.1007/s10654-017-0255-x
16. Guaraldi G, Meschiari M, Cozzi-Lepri A, Milic J, Tonelli R, Menozzi M, et al. Tocilizumab in patients with severe COVID-19: a retrospective cohort study. Lancet Rheumatol [Internet]. 2020 Aug 1 [cited 2020 Sep 24];2(8):e474–84. Available from: http://www.ncbi.nlm.nih.gov/pubmed/32835257
17. Mori S, Yoshitama T, Hidaka T, Hirakata N, Ueki Y. Effectiveness and safety of tocilizumab therapy for patients with rheumatoid arthritis and renal insufficiency: a real-life registry study in Japan (the ACTRA-RI study). Ann Rheum Dis [Internet]. 2015 Mar [cited 2020 Sep 24];74(3):627–30. Available from: http://www.ncbi.nlm.nih.gov/pubmed/25561361
18. Food and Drug Administration U. FDA: Tocilizumab (Actemra) Product Information Sheet [Internet]. 2013. [cited 2020 Sep 24]. Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/125276s092lbl.pdf
19. Charytan D, Kuntz RE. The exclusion of patients with chronic kidney disease from clinical trials in coronary artery disease. Kidney Int [Internet]. 2006 Dec [cited 2020 Sep 24];70(11):2021–30. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17051142
20. Swerdlow DI, Preiss D, Kuchenbaecker KB, Holmes M V, Engmann JEL, Shah T, et al. HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials. Lancet [Internet]. 2015 Jan 24 [cited 2020 Sep 24];385(9965):351–61. Available from: https://www.sciencedirect.com/science/article/pii/S0140673614611831