Constitutive |
|
|
|
|
Mcpt5-Cre; R-DTA |
Cre expression under the control of the Mcpt5
promoter; Cre-driven expression of DT |
CTMCs |
No |
109 |
Cpa3Cre+ (“Cre-Master”) |
Cre expression under the
control of the Cpa3 promoter |
CTMCs + MMCs |
Yes (~60%
reduction) |
110 |
Cpa3-Cre; Mcl-1fl/fl (“Hello Kitty”) |
Mcl-1
deletion under the control of the Cpa3 promoter |
CTMCs + MMCs |
Yes
(~60-80% reduction) |
111 |
Chm-Cre; Mcl-1fl/fl
|
Mcl-1 deletion under the control
of the baboon-α-chymase gene |
MMCs reduced; CTMCs normal |
Not
determined |
114 |
Inducible |
|
|
|
|
Mas-TRECK |
DT receptor expressed under the control of a MC-specific
IL-4 enhancer element |
CTMCs; MMCs not determined |
Transient
depletion; recovery of basophil populations 12 days after DT
administration |
112 |
Mcpt5-Cre; iDTR |
DT receptor expressed under the control of the Mcpt5
promoter |
CTMCs |
No |
109 |
Red mast cell and basophil (RMB) mouse |
DT receptor and bright red
td-Tomato fluorescent protein expressed under the control the β chain of
FcεRI (Ms4a2) |
CTMCs; MMCs not determined |
Transient depletion;
recovery of basophil populations 12 days after DT administration |
113 |