Model, designation Principle Type of MC affected Basophils affected Ref
Constitutive
Mcpt5-Cre; R-DTA Cre expression under the control of the Mcpt5 promoter; Cre-driven expression of DT CTMCs No 109
Cpa3Cre+ (“Cre-Master”) Cre expression under the control of the Cpa3 promoter CTMCs + MMCs Yes (~60% reduction) 110
Cpa3-Cre; Mcl-1fl/fl (“Hello Kitty”) Mcl-1 deletion under the control of the Cpa3 promoter CTMCs + MMCs Yes (~60-80% reduction) 111
Chm-Cre; Mcl-1fl/fl Mcl-1 deletion under the control of the baboon-α-chymase gene MMCs reduced; CTMCs normal Not determined 114
Inducible
Mas-TRECK DT receptor expressed under the control of a MC-specific IL-4 enhancer element CTMCs; MMCs not determined Transient depletion; recovery of basophil populations 12 days after DT administration 112
Mcpt5-Cre; iDTR DT receptor expressed under the control of the Mcpt5 promoter CTMCs No 109
Red mast cell and basophil (RMB) mouse DT receptor and bright red td-Tomato fluorescent protein expressed under the control the β chain of FcεRI (Ms4a2) CTMCs; MMCs not determined Transient depletion; recovery of basophil populations 12 days after DT administration 113