Box 1. Major discoveries/contributions of Dean Metcalfe.
- 1991 Consensus and classification of mastocytosis.
- 1991 & 1992. Demonstration of human mast cell origin from CD34+
progenitors and SCF to be a major growth factor for mast cells.
- 1995 Identification of KIT D816V mutation in systemic
mastocytosis.
- 2007 Identification of aberrant mast cells in idiopathic anaphylaxis.
- 2016 Description of a new mast cell-driven condition relating to
mechanoreceptors - hereditary vibratory urticaria.
- 2018 & 2021 Detection of exosomes that can transfer mutated KIT to
other cells and change their phenotype and function.
Figure legend
Figure 1. Dean Metcalfe