The clinical manifestation of coronavirus disease 2019 (COVID-19) overlap with other disorders especially cardiovascular diseases (CVD). We report a 58 years old female presented with syncope episodes and dyspnea on exertion with the left atrial mass, candidate for surgical removal and mitral valve replacement. Nearly 3 months later, she developed dyspnea, fever, and a sore throat cause to admit her with suspected COVID-19. During diagnostic evaluation, a larger LA mass detected that seemed to be COVID-19 induced organized thrombus with prosthetic mitral valve malfunction. the mass resected and immunohistochemistry revealed liposarcoma. The unusual early recurrence of liposarcoma and misdiagnosis with COVID-19 induced thrombosis are the hallmark of the present case.