Introduction:
CML is a myeloproliferative neoplasm characterized by a translocation between chromosomes (9, 22), resulting in a BCR-ABL fusion gene with tyrosine kinase activity. The CML-BP can transform into acute lymphoblastic leukemia (ALL) as well as acute myeloblastic leukemia [1]. In 2016, WHO has included AML with BCR/ABL+ gene as a separate provisional entity in its latest classification of myeloid neoplasms [1,2]. We report a case of CML-BP in a middle aged gentleman that posed a challenge to diagnose and differentiate it from de novo AML due to lack of a definite clinical criteria in such clinical scenarios [2].
Keywords: Chronic Myeloid leukemia, de Novo AML,BCR-ABL + AML, Philadelphia chromosome, T315I.