Sample Size
To demonstrate a clinically important reduction in the primary outcome,
a sample size of 712 is required, assuming a decrease in the proportion
of patients receiving invasive mechanical ventilation from 12% to 6%,
with power 80% and a two-sided significance level of 0.05.
Each individual contributing study may have a different sample size
based on their primary outcome, which will have been reported on the
individual trial registrations.