Synopsis of key findings
The present study found that 30.9% of patients develop functional
failure following (chemo)radiotherapy for locally advanced LSCC. The
multivariate analyses demonstrated that the current smokers were 6.8
times more likely to experience functional failure, while hemi-laryngeal
fixation conferred a significantly increased risk of loco-regional
recurrence (HR 3.4, 95% CI 1.4-8.4, p=0.007).