Study limitations and strengths
Selection bias inherent to a retrospective design notwithstanding, we
recognise that the principal limitation of our study relates to a
relatively small sample size and, by extension, limited number of NFL
events to analyse and to analyse subgroups (e.g. T stage). Not only does
this carry a propensity for type I or II statistical error, but also
restricted the number of predictive factors that could be examined. This
was compounded by use of relatively crude outcome measures, with no
availability of patient-reported functional outcome measures, leading
potentially to a lack of data granularity. Nevertheless, our study
included a homogenous group of patients with locally advanced LSCC for
whom robust follow-up data was collated. Furthermore, as outlined
previously we believe this study attempts to enrich the evidence-base
around an important clinical question, currently informed by a paucity
of data.