What’s already known about this topic?
Severe COVID-19 most frequently manifests with acute respiratory distress syndrome (ARDS) with hypoxemic respiratory failure, and macrophage activation syndrome (MAS). In both of these clinical conditions, overexpression of proinflammatory cytokines causes endothelial dysfunction and can result in vital organ injury, especially in the lungs. SP-A plays an important role in the anti-inflammatory balance in the alveoli.