What’s already known about this topic?
Severe COVID-19 most frequently manifests with acute respiratory
distress syndrome (ARDS) with hypoxemic respiratory failure, and
macrophage activation syndrome (MAS). In both of these clinical
conditions, overexpression of proinflammatory cytokines causes
endothelial dysfunction and can result in vital organ injury, especially
in the lungs. SP-A plays an important role in the anti-inflammatory
balance in the alveoli.