Data are Mean (SD) or Median [Min, Max]; *Compared with Control using Tukey test, p < 0.05;**Compared with Control using Tukey and Kramer Nemenyi test, p < 0.05.
Awake time to OAA/S 5 (s)
Figure 1. Study flow diagram.
Figure 2. Consecutive target propofol concentrations during gastrointestinal endoscopy for EC50 determination in control group. The red dot represents “non-responsive”; and the blue triangle represents “responsive”. The horizontal line represents the ED50. Propofol EC50 and its 95% confidence interval were 3.69 (2.59-4.78) μg/mL.
Figure 3. Consecutive target propofol concentrations during gastrointestinal endoscopy for EC50 determination in SK0.25 group. The red dot represents “non-responsive”; and the blue triangle represents “responsive”. The horizontal line represents the ED50. Propofol EC50 and its 95% confidence interval were 2.45 (1.85-3.05) μg/mL.
Figure 4. Consecutive target propofol concentrations during gastrointestinal endoscopy for EC50 determination in SK0.5 group. The red dot represents “non-responsive”; and the blue triangle represents “responsive”. The horizontal line represents the ED50. Propofol EC50 and its 95% confidence interval were 1.71 (1.15-2.27) μg/mL.
Figure 5. The time course of percent change to baseline in mean arterial pressure. T0 = baseline values; T1 = the target concentration achieved after TCI propofol; T2= 3 min after esketamine injection; T3 = at scope intubation and T4-x = by 3-min intervals during the procedure.
Figure 6. The time course of percent change to baseline in heart rate. T0 = baseline values; T1 = the target concentration achieved after TCI propofol; T2= 3 min after esketamine injection; T3 = at scope intubation and T4-x = by 3-min intervals during the procedure.