Table 3. CSMS, SS and MS for the entire study periods
ILIT after SCIT- 10 000 ILIT after SCIT- 10 000 ILIT after SCIT- 10 000 ILIT after SCIT- 10 000 ILIT after SCIT- 10 000 ILIT after SCIT- 10 000
CSMS mean (SD [95%CI]), median (IQR) SS mean (SD [95%CI]), median (IQR) SS mean (SD [95%CI]), median (IQR) MS mean (SD [95%CI]), median (IQR)
Active N= 13
Before treatment
97.8 (48.8 [68.3-127.3]), 110.1 (53.11–132.8) 43.5 (21.3 [30.6-56.5]), 45.6 (26.3–58.0) 54.3 (34.7 [33.4-75.3]), 57.5 (20.5–85.0) 54.3 (34.7 [33.4-75.3]), 57.5 (20.5–85.0)
After treatment
72.3 (44.8 [45.3-99]), 76.3 (22.7–109.9) 36.7 (23.6 [22.5-51.0]), 43.7 (13.4–53.2) 36.0 (33.4 [15.8-56.1]), 27.5 (3.0–63.3) 36.0 (33.4 [15.8-56.1]), 27.5 (3.0–63.3)
P-value before vs. after treatment † 0.005 0.15 0.003 0.003
Placebo N=11
Before treatment
61.5 (40.7 [34.2-88.9]), 61.9 (24.9-83.7) 24.4 (13.5 [15.3-33.5]), 27.4 (10.1-36.2) 37.4 (34.8 [13.8-60.5]), 33.0 (15.0–41.5) 37.4 (34.8 [13.8-60.5]), 33.0 (15.0–41.5)
After treatment,
55.7 (45.1 [25.5-86.1]), 45.1 (29.9-65.7) 24.8 (15.1 [14.7-35.0]), 21.8 (13.1–32.6) 31.0 (33.3 [8.8-53.4]), 28.0 (6.5–33.5) 31.0 (33.3 [8.8-53.4]), 28.0 (6.5–33.5)
P-value before vs. after treatment † 0.24 0.90 0.068 0.068
ILIT de novo- 3000 ILIT de novo- 3000 ILIT de novo- 3000 ILIT de novo- 3000 ILIT de novo- 3000 ILIT de novo- 3000
CSMS mean (SD [95%CI]) SS mean (SD [95%CI]) MS mean (SD [95%CI]) MS mean (SD [95%CI])
Active N=16
Before treatment
90.4 (30.9 [74.0–107.0])
49.1 (16.5 [40.3–57.9])
44.5 (27.8 [29.7-59.3])
44.5 (27.8 [29.7-59.3])
After treatment, 68.9 (28.9 [53.5–84.3]) 36.7 (17.6 [27.4–46.1]) 30.3 (20.3 [19.5–41.2]) 30.3 (20.3 [19.5–41.2])
P-value before vs. after treatment ‡ 0.003 0.004 0.005 0.005
Placebo N=18
Before treatment
104.2 (42.7 [82.9-125.5])
51.2 (23.7 [39.4-63.0])
53.0 (27.7 [39.2-66.8])
53.0 (27.7 [39.2-66.8])
After treatment 74.8 (34.7 [57.5-92.0]) 40.9 (16.8 [32.5-49.2]) 33.9 (24.3 [21.8-46.0]) 33.9 (24.3 [21.8-46.0])
P-value before vs. after treatment‡ 0.003 0.02 0.005 0.005
† Wilcoxon matched pairs signed rank test. ‡ Paired t-test. IQR interquartile range. † Wilcoxon matched pairs signed rank test. ‡ Paired t-test. IQR interquartile range. † Wilcoxon matched pairs signed rank test. ‡ Paired t-test. IQR interquartile range. † Wilcoxon matched pairs signed rank test. ‡ Paired t-test. IQR interquartile range. † Wilcoxon matched pairs signed rank test. ‡ Paired t-test. IQR interquartile range. † Wilcoxon matched pairs signed rank test. ‡ Paired t-test. IQR interquartile range.