ILIT after SCIT- 10 000 | ILIT after SCIT- 10 000 | ILIT after SCIT- 10 000 | ILIT after SCIT- 10 000 | ILIT after SCIT- 10 000 | ILIT after SCIT- 10 000 |
CSMS mean (SD [95%CI]), median (IQR) | SS mean (SD [95%CI]), median (IQR) | SS mean (SD [95%CI]), median (IQR) | MS mean (SD [95%CI]), median (IQR) | ||
Active N= 13 |
Before treatment
|
97.8 (48.8 [68.3-127.3]), 110.1 (53.11–132.8) | 43.5 (21.3 [30.6-56.5]), 45.6 (26.3–58.0) | 54.3 (34.7 [33.4-75.3]), 57.5 (20.5–85.0) | 54.3 (34.7 [33.4-75.3]), 57.5 (20.5–85.0) |
After treatment
|
72.3 (44.8 [45.3-99]), 76.3 (22.7–109.9) | 36.7 (23.6 [22.5-51.0]), 43.7 (13.4–53.2) | 36.0 (33.4 [15.8-56.1]), 27.5 (3.0–63.3) | 36.0 (33.4 [15.8-56.1]), 27.5 (3.0–63.3) | |
P-value before vs. after treatment † | 0.005 | 0.15 | 0.003 | 0.003 | |
Placebo N=11 |
Before treatment
|
61.5 (40.7 [34.2-88.9]), 61.9 (24.9-83.7) | 24.4 (13.5 [15.3-33.5]), 27.4 (10.1-36.2) | 37.4 (34.8 [13.8-60.5]), 33.0 (15.0–41.5) | 37.4 (34.8 [13.8-60.5]), 33.0 (15.0–41.5) |
After treatment,
|
55.7 (45.1 [25.5-86.1]), 45.1 (29.9-65.7) | 24.8 (15.1 [14.7-35.0]), 21.8 (13.1–32.6) | 31.0 (33.3 [8.8-53.4]), 28.0 (6.5–33.5) | 31.0 (33.3 [8.8-53.4]), 28.0 (6.5–33.5) | |
P-value before vs. after treatment † | 0.24 | 0.90 | 0.068 | 0.068 | |
ILIT de novo- 3000 | ILIT de novo- 3000 | ILIT de novo- 3000 | ILIT de novo- 3000 | ILIT de novo- 3000 | ILIT de novo- 3000 |
CSMS mean (SD [95%CI]) | SS mean (SD [95%CI]) | MS mean (SD [95%CI]) | MS mean (SD [95%CI]) | ||
Active N=16 |
Before treatment
|
90.4 (30.9 [74.0–107.0])
|
49.1 (16.5 [40.3–57.9])
|
44.5 (27.8 [29.7-59.3])
|
44.5 (27.8 [29.7-59.3])
|
After treatment, | 68.9 (28.9 [53.5–84.3]) | 36.7 (17.6 [27.4–46.1]) | 30.3 (20.3 [19.5–41.2]) | 30.3 (20.3 [19.5–41.2]) | |
P-value before vs. after treatment ‡ | 0.003 | 0.004 | 0.005 | 0.005 | |
Placebo N=18 |
Before treatment
|
104.2 (42.7 [82.9-125.5])
|
51.2 (23.7 [39.4-63.0])
|
53.0 (27.7 [39.2-66.8])
|
53.0 (27.7 [39.2-66.8])
|
After treatment | 74.8 (34.7 [57.5-92.0]) | 40.9 (16.8 [32.5-49.2]) | 33.9 (24.3 [21.8-46.0]) | 33.9 (24.3 [21.8-46.0]) | |
P-value before vs. after treatment‡ | 0.003 | 0.02 | 0.005 | 0.005 | |
† Wilcoxon matched pairs signed rank test. ‡ Paired t-test. IQR interquartile range. | † Wilcoxon matched pairs signed rank test. ‡ Paired t-test. IQR interquartile range. | † Wilcoxon matched pairs signed rank test. ‡ Paired t-test. IQR interquartile range. | † Wilcoxon matched pairs signed rank test. ‡ Paired t-test. IQR interquartile range. | † Wilcoxon matched pairs signed rank test. ‡ Paired t-test. IQR interquartile range. | † Wilcoxon matched pairs signed rank test. ‡ Paired t-test. IQR interquartile range. |