Introduction
Congenital ichthyosis is a heterogeneous group of Mendelian disorders characterized by hyperkeratosis and extensive scaling of the epidermal skin layer due to mutations in genes that play a critical role in epidermal differentiation. Several genetic mutations have been associated with the disease, demonstrating an autosomal recessive, autosomal dominant, and X-linked recessive pattern of inheritance. (1,2) Multiple sclerosis (MS) is an autoimmune inflammatory disease primarily involving the central nervous system, causing variable neurologic manifestations which can ultimately lead to neurologic deterioration. (3,4)
In this study, we describe a case of congenital ichthyosis that presented with signs and symptoms of MS to our clinic. Although the co-occurrence of the disease can be a coincidence, the event is uncommon and has been rarely reported.