WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT
Nemonoxacin is one of the latest quinolones used to treat infections caused by susceptible pathogens, especially S. pneumoniae andS. aureus . Although it is primarily eliminated via kidneys, the pharmacokinetics and safety of nemonoxacin have not been studied in patients with severe renal impairment. PPK/PD analysis is the economic and efficient practice to guide rational drug use based on individual characteristics.