Urinary Excretion
The excretion of nemonoxacin was described by urinary recovery with the
equation below:
Recovery =\(\frac{\sum{\mathrm{(}\mathrm{C}_{\mathrm{drug,}\mathrm{\ }\mathrm{i}}\mathrm{\times}\mathrm{V}_{\mathrm{urine,}\mathrm{\ }\mathrm{i}}\mathrm{)}}}{\mathrm{\text{Dose}}}\)
where the recovery was calculated by the sum of multiplying
concentration (C Drug, i ) and urine volume
(V Urine , i) in each collection
interval divided by Dose . The accumulative excretion of
nemonoxacin was 23.4±6.5% in renal impairment group and 66.1±16.8% in
healthy controls (Figure 5). The renal clearance (CLr)
of nemonoxacin was 1.31±0.39 L/h in renal impairment group and 7.13±1.92
L/h in healthy controls, which was calculated as\(\sum{\mathrm{(}\mathrm{C}_{\mathrm{drug,}\mathrm{\ }\mathrm{i}}\mathrm{\times}\mathrm{V}_{\mathrm{urine,}\mathrm{\ }\mathrm{i}}\mathrm{)}}\)/AUC
over 72 hours.