Nemonoxacin Dosage
Adjustment in Patients with Severe Renal Impairment Based on Population
Pharmacokinetic and Pharmacodynamic Analysis
Yi Li,a, d, e Jianda Lu,b Yue
Kang,a, d, e Xiaoyong Xu,f Xin
Li,a, d, e Yuancheng Chen,c, d, eKun Wang,h Xiaofen Liu,a, d, e Yaxin
Fan,a, d, e Hailan Wu,a, d, e Yu
Wang,a, d, e Jiali Hu,a, d, eJicheng Yu,c, d, e Jufang Wu,c, d, eBeining Guo,a, d, e Yingyuan Zhang,a,
d, e Xin Zeng,a, d, e, g Ming
Zhao,g Jun Xue,b † Jing Zhanga, c, d, e †
a Institute of Antibiotics, Huashan Hospital, Fudan
University, Shanghai, China
b Department of Nephrology, Huashan Hospital, Fudan
University, Shanghai, China
c Phase I Unit, Huashan Hospital, Fudan University,
Shanghai, China
d China Key Laboratory of Clinical Pharmacology of
Antibiotics, Ministry of Health, Shanghai, China
e National Clinical Research Center for Geriatric
Diseases, Huashan Hospital, Fudan University,
Shanghai, China
f Shanghai Medical College, Fudan University,
Shanghai, China
g Center for Drug Evaluation, National Medical
Products Administration, Beijing, China
h Certara Strategic Consulting China, Shanghai, China
Yi Li and Jianda Lu contributed equally to this study.
† Corresponding author:
Jing Zhang, PhD, E-mail:zhangj_fudan@aliyun.com,
Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai,
China, 200040.
Jun Xue, MD, E-mail:xuejun@fudan.edu.cn,
Department of Nephrology, Huashan Hospital, Fudan University, Shanghai,
China, 200040.
Running title: Nemonoxacin Dosage Adjustment in Severe Renal
Impairment