MATERIALS AND METHODS
This study was conducted in accordance with the principles of
Declaration of Helsinki and Good
Clinical Practices guidelines. The protocol and amendments were approved
by the Huashan Hospital Institutional Review Board, Fudan University, on
August 3, 2016 (no. 2016-217). All the eligible subjects enrolled at a
single center in China from April 2017 to November 2019 and provided
written informed consent prior to any study procedure.