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\begin{document}

\title{Energetic Cost of Biosynthesis Is a Missing Link between Growth and
Longevity in Mammals}



\author[1]{Chen Hou}%
\affil[1]{Missouri University of Science and Technology}%


\vspace{-1em}



  
  \date{June 17, 2024}


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\begin{abstract}
The physiological mechanism underlying the well-established negative
correlation between Gompertz postnatal growth constant and lifespan
across mammalian species remains unclear. For the first time, this study
shows that the energetic cost of biosynthesis plays a key role in this
correlation. Previously, this cost has been thought to be a constant
across species, and therefore was not considered a contributor to the
variation in any life history traits. Here, we employ a newly proposed
model to explain the physiological effect of the variation in this
energetic cost on aging, and how it links growth and lifespan. The
conventional life history theory suggested a tradeoff between growth and
health of animals, but the new findings here suggest that allocating
more energy to biosynthesis may reduce the energetic requirement of
somatic maintenance and extend lifespan, and therefore they reveal a
more complex nature of the tradeoff.%
\end{abstract}%



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\textbf{Hosted file}

\verb`Final Oct 17 2023.docx`  available at \url{https://authorea.com/users/393278/articles/672775-energetic-cost-of-biosynthesis-is-a-missing-link-between-growth-and-longevity-in-mammals}

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\end{document}

