Variable Name Value Relevant Source
Simulation Variable
Initial number of beads 0
Grid Number 2500
Grid dimension 10 Micron
Confluence Half of total grid (1250)
Number of control-steps 20, 50, 400 (variable) Assumed
Control Time interval
8-hour, 3.2-hour , 24 minutes
Number of beads that can be added at each control step
10
Initial number of naïve cells to begin with in control area
20
Assumed
Total time 160 hours (weeklong growth)
Cell Variable
Mean value of Regeneration Age
2 days
Assumed
Maximum age at which a cell can regenerate
3.5 days
Assumed
Probability of conversion 45, 90 (\(\ \frac{\text{Conversion}}{100\ \times\ Collisions}\ \)) Assumed
Exhaustion Rate 1,4 (\(\frac{\text{Unit\ potency}}{100\ collision}\)) Assumed
Natural Exhaustion 1, 10 (\(\ \frac{\text{Unit\ potency}}{\ 100\ \times\ timesteps\ }\ \)) Assumed
Regeneration Rate 1, 5 (\(\frac{\text{Regeneration}}{100\ \times\ timesteps}\)) Assumed
Asymmetric regeneration True/False Assumed
Potency value above which a cell is considered robust
0.8
Assumed
Potency value below which a cell is considered exhausted
0.2
Assumed