Other rare types of clinical presentation
Another rare presentation of MOGAD is found in children that show similar symptoms of ADEM, however, with a more progressive disease course (61). Here clinical course and symmetrical confluent cerebral MRI changes resemble that of children with leukodystrophy, hence the term leukodystrophy-like phenotype. Recently, overlapping central and peripheral nervous system syndromes have been described as potential additional MOGAD phenotypes, including cranial nerve involvement, myeloradiculitis, inflammatory neuropathies and combined central and peripheral demyelination syndromes (62–66).