Subgroup analyses
As listed in Table 2, in subgroup analyses by study design, the results
demonstrated the consistent protective role of OAC use in reducing the
incidence of dementia, with the low heterogeneity for prospective
studies (Supplementary Figure S1); by patients with the history of prior
stroke, the direction of effects were similar; by setting observational
window, the pooled RR did not reach the statistically significant level
for studies with observational window (RR [95%CI] =0.75 [0.51,
1.10], I2=98.8%; P =0.000) (Supplementary
Figure S2).