Weight
Data presented in Figure 3 suggest potential quadratic correlation
between weight and peak plasma lidocaine levels (p=0.0516). At weights
between 10kg and 12kg, there is a trend toward higher peak plasma
lidocaine concentrations. The covariates have not reached significance
level but this could be due to the small sample size. It suggests an
area for further investigation regarding patients’ with smaller weights
reaching higher peak plasma levels.
As demonstrated in Figure 1, weight and age are strongly correlated
within our cohort. Weights between 10kg and 12kg correspond to an age of
18 months. This adds further support to our results of higher peak
plasma lidocaine concentrations in <18months old patients
following airway topicalisation.