Weight
Data presented in Figure 3 suggest potential quadratic correlation between weight and peak plasma lidocaine levels (p=0.0516). At weights between 10kg and 12kg, there is a trend toward higher peak plasma lidocaine concentrations. The covariates have not reached significance level but this could be due to the small sample size. It suggests an area for further investigation regarding patients’ with smaller weights reaching higher peak plasma levels.
As demonstrated in Figure 1, weight and age are strongly correlated within our cohort. Weights between 10kg and 12kg correspond to an age of 18 months. This adds further support to our results of higher peak plasma lidocaine concentrations in <18months old patients following airway topicalisation.