Total dose volume of local anaesthetic
Data in Figure 4 suggest a significant quadratic relationship between volume of lidocaine utilised and its peak plasma levels (p=0.0352).
Airway topicalisation using a total dose volume between 2 and 3mls of 2% lidocaine led to higher peak plasma levels when compared to <2ml total dose volume. This suggests that using low volume, high concentration local anaesthetic solution for airway topicalisation may have a superior safety profile.