Dose
Dosing regimes did vary between practitioners dependent upon usual
practice. Dosing regimes in the study comprised of 5.0
(4.93,5.0)[3.0,5.0] mg/kg, median (IQR)[range]. P-values from
Mann-Whitney U test demonstrate no significant difference between the
distribution of peak lidocaine plasma levels between doses at 5mg/kg and
<5mg/kg (p=0.18). However, a narrow IQR within toxic limits
has been suggested with doses <5mg/kg. This could imply a
safer dosing profile, with no clinical adverse effects demonstrated for
both the patient and surgical conditions.
Secondary outcomes