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\begin{document}

\title{Interim PET-CT: Predictive marker and therapeutic modification tool of
pediatric Hodgkin lymphoma}



\author[1]{Pankaj Dwivedi}%
\author[2]{Manish Mathankar}%
\author[2]{Chaitali Bongulwar}%
\author[2]{Ketan Modak}%
\author[2]{Madhabika Chakraborty}%
\author[1]{Atul Kapse}%
\author[2]{Meena Pangarkar}%
\author[1]{Nitin Manvani}%
\affil[1]{National Cancer Institute}%
\affil[2]{National Cancer Institute Nagpur}%


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  \date{May 26, 2024}


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\begin{abstract}
Hodgkin lymphoma is a haematolymphoid malignancy seen in pediatric and
adult age groups with an excellent outcome. The current priority of the
treatment has been a reduction of acute and chronic morbidities without
compromising outcomes. PET-CT scan is an integral component in
prognosticating and determining outcomes in Hodgkin lymphoma. Recent
studies have highlighted the role of interim PET-CT scan in choosing
future therapy. The evidence to support the role of interim PET-CT scan
in childhood Hodgkin lymphoma is limited. The aim of the study is to
analyse the role of interim PET-CT in the management of childhood HL,
and to investigate survival outcomes of children treated at our
institute. This is a retrospective study and included all the children
with HL treated at our institute in last five years. All the children
were treated as per ESMO guidelines. Interim PET-CT scan was done after
two cycles of chemotherapy. The correlation of various possible risk
factors with the outcomes was examined. Only the interim PET/CT findings
were associated with the results. At median follow-up of 34 months, the
event free survival (EFS) was 95.7\% and overall survival (OS) was
100\%. Interim PET-CT plays an important role in treatment modification
without compromising on the outcomes in children with HL. Survival rates
were consistent with those reported in published literature.%
\end{abstract}%



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\verb`Interim PET CT May4.docx`  available at \url{https://authorea.com/users/405623/articles/647660-interim-pet-ct-predictive-marker-and-therapeutic-modification-tool-of-pediatric-hodgkin-lymphoma}

\textbf{Hosted file}

\verb`Table cancer report.docx`  available at \url{https://authorea.com/users/405623/articles/647660-interim-pet-ct-predictive-marker-and-therapeutic-modification-tool-of-pediatric-hodgkin-lymphoma}

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