Study Design and data collection
44 DLBCL cases diagnosed as a result of lymph node biopsy in hematology
department between June 2007 and September 2014 were included in the
study. Patients whose treatment and polyclinic follow-ups were accepted
in our department were included in the study. Pathology preparations of
13 patients for whom reactive hyperplasia was found in the lymph node
biopsy and no other malignancies were taken as the control group.
The cut-off values of the laboratory parameters used in the study were
chosen as the upper limit of their normal values. The term partial
remission was defined as a total reduction of more than 50% of the
product of the perpendicular dimensions of the measurable lesions, while
the term complete remission was defined for patients who had a complete
healing with no signs of disease in their post-treatment laboratory
values and imaging(7).
Immunohistochemical VEGF, PDGFR, Thrombospondin stain was performed with
the streptovidin-avidin-biotin method. The preparations evaluated at 40
magnification under light microscopy with a hematologist and a
pathologist were scored as 0, 1, 2, 3 as per the staining ratio of the
cells.