Abstract
Purpose: We aimed to investigate the relationship between the
staining rates of thrombospondin-1, VEGF and PDGFR-in tissue
preparations in patients diagnosed with DLBCL as a result of
lymphadenopathy biopsy and their clinical features at the time of
diagnosis, response to treatment and prognosis.
Materials and Methods: For this purpose, a total of 44 patients
with a diagnosis of DLBCL, 24 male and 20 female, and 13 patients
diagnosed with control reactive lymphadenopathy, 6 male and 7 female
were enrolled. After the pathology preparations of the patient and
control groups were stained immunohistochemically with VEGF, PDGFR-β,
thrombospondin-1 stains, the clinical characteristics of the patients
and the relationship between survival analysis and staining rates were
analyzed statistically.
Results: When the patients were compared with the control group
in terms of VEGF, PDGFR-β, thrombospondin-1 staining rates, we found
that staining with PDGFR-β was lower in patients (p = 0.009). Although
it was not statistically significant for PDGFR-β, it was observed that
5-year OS and PFS values were low in patients with high levels of
expression, on the contrary, 5-year OS was low in patients with high
thrombospondin staining rate. A negative correlation was seen between
thrombospondin-1 and PDGFR-β (p=0.003, r=-0.440).
Conclusion: As a result, although no relationship was found
between VEGF and survival in our study, it was observed that PDGFR-β and
thrombospondin-1 were effective in prognosis. A negative correlation was
seen between thrombospondin-1 and PDGFR-β.
Keywords: Diffuse large B cell lymphoma, thrombospondin-1,
VEGF, PDGFR-β, prognosis