Abstract
Aim: Percutaneous nephrolithotomy (PNL) and retrograde
intrarenal surgery (RIRS) are common surgical methods in the treatment
of kidney stones. Possible effects on kidneys are an important factor in
determining the surgical procedure and the surgical method. In our
study, kidney injury molecule-1 (KIM-1) and myo-inositol oxygenase
(MIOX) were used to compare acute kidney injury in patients that
underwent PNL and RIRS.
Material and Method: Eighty patients aged 20 to 75, who
underwent PNL or RIRS in our urology clinic between November 2018 and
February 2020 were included in the study. In this prospective study, the
demographic characteristics, stone size, operation time, preoperative
and postoperative hemoglobin and biochemistry values of the patients
were recorded. 5 cc blood samples taken from the patients before the
operation and at the fourth hour after the operation were centrifuged
and kept at -80 °C, and the KIM-1 and MIOX levels were measured in the
biochemistry department.
Results: There was no difference between the groups in terms of
demographic data; however,the operation time and length of hospital stay
were significantly longer in the PNL group. The mean increase in MIOX
was 10.583±9.73 ng/ml and 7.501±16.46 ng/ml in the PNL and RIRS groups,
respectively. Although there was a statistically significant increase in
both groups, this increase was greater in the PNL group. A significant
increase was observed only in the PNL group in the postoperative period
(p=0.003).
Discussion and Conclusion: The findings of the study suggest
that the PNL procedure causes more damage to the kidneys than RIRS.