Main outcome measures
The risk of COD in offspring
Results :
A significant association was shown between maternal TL shortening (per
standard deviation) and a 29% increased risk of VSD in offspring (OR
1.29(95% CI 1.04-1.61), P= 0,02), which remained significant after
additional adjustment for maternal age (adjOR 1.25(95% CI 1.01-1.55),
P= 0,04). No association between maternal TL and the risk of overall COD
in offspring was observed.ConclusionShortening of maternal TL, due to maternal conditions including age, is
associated with an approximately 1.3-fold increased risk, per SD in
TL-shortening, of VSD in the offspring. These findings need further
confirmation in other studies on the predictive value of maternal TL.