Introduction
Shingles is a disease that negatively affects the quality of life of patients with symptoms such as pain and itch1. The severity of herpetic pain (HP) accompanying in the acute period constitutes a risk factor for developing post-herpetic neuralgia2. HP affects the daily lives of patients negatively both physically and emotionally by causing symptoms such as sleep disorders, depression, weight loss, and chronic fatigue3. Herpetic itch (HI), which has not been studied HP; it can accompany alone or HP, and patients injure themselves by scratching due to HI4. There is a complex relationship between HP and HI, and the answer to the question of which patients develop HP and in which HI is not clear 5.
Vitamin B 12 supports myelinization and axonal transport, helps the regeneration of peripheral nerve cells and is used in the treatment of neuropathic pain due to this feature6. Additionally, it has been reported that vitamin b 12 deficiency plays a role in the etiology of neuropathic itching by causing small-fiber neuropathy7. Although HP and HI be associated with neural tissue damage and functional abnormalities such as subepidermal nerve plexus, afferent fibers, and epidermal nerve fiber endings, the etiopathogenesis has not been clarified yet8. In this study, it was investigated the effect of vitamin B12 ​​on itching and pain symptoms that patients with zona have been in the acute period.