HLA |
HLA–A |
HLA class I histocompatibility antigen, A |
Peptide antigen presentation to the immune system |
[170-172] |
|
HLA-DRB1 and DQA1 |
HLA class II histocompatibility antigen,
DRB1 and DQA1 |
Peptide antigen presentation to the immune system |
[171, 173] |
|
HLA class III |
HLA class III histocompatibility antigen |
Involved in inflammation and cytokine production |
[174] |
Immune- regulatory |
AIRE |
Autoimmune regulator |
Maintenance of
immune tolerance |
[175, 176] |
|
BACH2 |
Transcription regulator protein BACH2 |
B cell
transcriptional repressor encodes a transcriptional repressor of B
cells, which is a key regulator of CD4+ T-cell differentiation that
prevents inflammatory disease by controlling the balance between
tolerance and immunity |
[168] |
|
C1QTNF6 |
Complement C1q tumour necrosis factor-related
protein 6 |
Induces monocyte IL-10 expression |
[171] |
|
CASP7 |
Caspase-7 |
Executor protein of apoptosis and
inflammation |
[168] |
|
CCR6 |
Chemokine-cytokine receptor 6 |
Regulates
differentiation and function of B and T lymphocytes and dendritic cells |
[171, 174] |
|
CD44 |
CD44 antigen |
Involves in T cell development |
[168] |
|
CD80 |
T‑lymphocyte activation antigen CD80 |
Co-stimulates
activation of T cells |
[168] |
|
CLNK |
Cytokine-dependent hematopoietic cell linker |
Positively regulates immune-receptor signalling |
[168] |
|
CTLA4 |
Cytotoxic T‑lymphocyte protein 4 |
Inhibition of T
cells |
[177-179] |
|
CXCR5 |
C-X-C chemokine receptor type 5 |
Involves in B
lymphocyte migration |
[169] |
|
FASLG |
FAS ligand |
Regulate immune apoptosis |
[180] |
|
FOXP1 |
Forkhead box protein P1 |
Regulates B cell development |
[181] |
|
FOXP3 |
Forkhead box protein P3 |
Regulates development and
function of regulatory T cells |
[182] |
|
GZMB |
Granzyme B |
Mediates the process of immune-induced
cell death with contribution of cytotoxic T lymphocytes and natural
killer cells |
[171, 183] |
|
IFIH1 |
Interferon-induced helicase C domain 1 |
Regulates
innate immune response |
[168] |
|
IKZF4 |
Zinc finger protein Eos |
Regulates T cell activation |
[168, 169] |
|
IL2RA |
Interleukin‑2 receptor subunit alpha |
Regulates
regulatory T cells |
[169, 171] |
|
NLRP1 |
NACHT leucine-rich-repeat protein 1 |
Regulates innate
immune system |
[42, 184-186] |
|
PTPN22 |
Lymphoid protein tyrosine phosphatase non-receptor
type 22 |
Negative regulation of T cell activation |
[171,
187-192] |
|
SH2B3 |
SH2B adapter protein 3 |
Development of B and T
lymphocytes |
[168] |
|
SLA |
Src-like-adapter |
Regulates antigen receptor signalling |
[168] |
|
TOB2 |
Protein TOB2 |
Involves in T cell tolerance |
[168] |
|
TSLP |
Thymic stromal lymphopoietin |
Cytokine regulator of
maturation of skin dendritic cells and T cells |
[182] |
|
UBASH3A |
Ubiquitin-associated and SH3 domain–containing A
protein |
Suppresses T cell receptor signaling |
[171] |
|
XBP1 |
X‑box-binding protein 1 |
Regulator of major
histocompatibility complex class II |
[182, 193] |
Melanocyte function |
ASP |
Agouti signalling protein |
Melanogenesis regulator via MC1R |
[194] |
|
FOXD3 |
Forkhead box D3 |
Regulator of melanoblast development |
[195] |
|
MC1R |
Melanocortin 1 receptor |
Regulator of melanogenesis |
[168, 194] |
|
OCA2 |
OCA2 gene |
Melanosomal transporter |
[168] |
|
PMEL |
Melanocyte-specific protein PMEL |
Structural
organization of premelanosomes |
[169] |
|
TYR |
Tyrosinase |
Regulator of melanogenesis |
[171,
196] |
|
ZMIZ1 |
Zinc finger protein MIZ type 1 |
Regulates development,
function and survival of melanocytes |
[174, 197] |
Metabolism-related genes |
ACE |
Angiotensin-converting enzyme |
Regulator of inflammation and blood pressure |
[198] |
|
CAT |
Catalase |
Protects cells from oxidative stress by
breakdown of hydrogen peroxide |
[199-201] |
|
EDN-1 |
Endothelin-1 |
Regulator of melanocyte growth and
function |
[202] |
|
LPP |
Lipoma-preferred partner |
Potential co‑activator |
[171] |
|
RERE |
Arginine–glutamic acid dipeptide repeats protein |
Regulates cell apoptosis |
[171] |
|
RNASET2 |
Ribonuclease T2 |
Oxidative stress regulator |
[174] |