Risk factors for development of grade III/ IV aGVHD
Because aGVHD grade III/IV adversely affected survival, we analyzed risk factors for its development as shown in TABLE 3 Risk factors for developing aGVHD grade III/IV. The risk of aGVHD grade III/IV was higher in patients receiving HLA mismatched donor transplant (OR 3.4 [95%CI 1.1-11.2]. However, not all recipients of mismatched donor transplants were at risk of aGVHD grade III/IV. Only the recipients of mismatched unrelated donor HCTs comparing to MRD had an increased risk of grade III/IV aGVHD (OR 10.4 [95% CI 2.5-47.6]). Among recipients of ≥2 Ag mismatched related donor transplants, there were no cases of aGVHD grade III/IV. The use of mismatched cord blood donors was not associated with slight increase in risk of aGVHD grade III/IV in comparison with MRD (OR 1.3 [95% CI 0.1-8.0]).