Address for correspondence:
Dr. Alexander Francke
Helios Klinikum Pirna
Struppener Str. 13, 01797, Pirna, Germany
Tel.: +49 3501 71185067
Fax.: +49 3501 71185042
Email: alexander.francke@helios-gesundheit.de
Manuscript information: 2 figures and 4 tables.
Word count: Abstract, 248; total manuscript 3451.
Disclosures: all other authors report no conflicts of interest. No financial support by third-parties or any grand was received. The data that support the findings of this study are available from the corresponding author upon reasonable request. The current study was a single-centre prospective trial performed in compliance with the guidelines for good clinical practice and the Declaration of Helsinki. The study was approved by the institutional ethical review board. All data were collected, managed and analysed at the Klinikum Pirna (ethics votum University of Dresden: EK 28409202). All patients provided informed consent.