THE IMPORTANCE OF MATERNAL ISCHEMIA MODIFIED ALBUMIN, NON STRESS
TEST AND DOPPLER ULTRASONOGRAPHY IN FORESEEING PERINATAL ASPHYXIA
Background: The aim of this study is to evaluate the importance
of ischemia changed albumin, in foreseeing fetal asphyxia and comparing
it between normal and preeclamptic pregnant.
Method: We planned our study as a prospective case-controlled
study between May 2011 and June 2013. We recruited 104 pregnant women
complicated by preeclampsia and 110 healthy pregnant women in the study.
Doppler ultrasonography, non-stress test and fetal biometric
measurements were performed. Venous blood samples taken to measure
ischemia modified albumin (IMA). The presence of fetal hypoxia/acidosis
was analyzed by conducting post-natal cord blood gas examination and
1.-5. minutes APGAR scoring.
Results: IMA levels in the preeclamptic group were found
statistically high (p<0,0001). The correlations between
umbilical artery doppler systolic/diastolic (S/D) ratio, brain sparing
effect, non stress test and IMA analyzed. We have found IMA
statistically high when S/D ratio is above 2 standard deviations
(preeclampsia; 11.83±1.33 vs 19.62±1.56 p<0.001, control;
10.28±1.57 vs 18.09±2.13 p<0.001) or brain sparing effect
started (preeclampsia; 25.59±2.48 vs 9.16±1.99 p<0.001,
control; 16.37±1.97 vs 6.72± 1.53 p<0.001) or abnormal NST
findings occurred (preeclampsia; 10.69±1.92 vs 20.72±1.15
p<0.001, control; 7,42±1,94 vs 9,72±2,19 p<0.001).
Conclusions: Maternal IMA levels are found high in preeclamptic
pregnant women and it can be used as a biomarker for determining fetal
wellbeing.