Conclusion:
COVID-19 mainly in severe cases in addition to lung involves different organs such as heart, liver, and kidney, as well as hematological and nervous system, and induce multi-organ failure. SARS-COV2 may directly invade the host cells of different organs through the ACE2 receptor due to the presence of this receptor in these organs. On the other hand, activation of the complement system, cytokine storm, dysregulated immune responses, coagulation dysfunction, and infiltration of inflammatory cells in SARS-CoV2 infection can induce the multi-organ failure in these patients. Consequently, increasing the knowledge on the pathophysiology of SARS-COV2-induced multi-organ failure may ultimately result in better ways to treat COVID-19 patients and decrease the associated morbidity and mortality.