Conclusion:
COVID-19 mainly in severe cases in addition to lung involves different
organs such as heart, liver, and kidney, as well as hematological and
nervous system, and induce multi-organ failure. SARS-COV2 may directly
invade the host cells of different organs through the ACE2 receptor due
to the presence of this receptor in these organs. On the other hand,
activation of the complement system, cytokine storm, dysregulated immune
responses, coagulation dysfunction, and infiltration of inflammatory
cells in SARS-CoV2 infection can induce the multi-organ failure in these
patients. Consequently, increasing the knowledge on the pathophysiology
of SARS-COV2-induced multi-organ failure may ultimately result in better
ways to treat COVID-19 patients and decrease the associated morbidity
and mortality.