Rim M. Harfouch
Department of Microbiology and Biochemistry, Faculty of Pharmacy,
Tishreen University, Latakia, Syria.
Corresponding author’s Email:
rimharfouch@tishreen.edu.sy
Abstract :
Coronavirus disease 2019 (COVID-19), which is caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), is a life-threatening
disease, especially in elderly individuals and those with comorbidities.
The predominant clinical manifestation of COVID-19 is respiratory
dysfunction, while neurological presentations are increasingly being
recognized. SARS-CoV-2 invades host cells primarily via attachment of
the spike protein to the angiotensin-converting enzyme 2 (ACE2) receptor
expressed on cell membranes. Patients with Alzheimer’s disease (AD) are
more susceptible to SARS-CoV-2 infection and prone to severe clinical
outcomes. Recent studies have revealed some common risk factors for AD
and COVID-19. An understanding of the association between COVID-19 and
AD and the potential related mechanisms may lead to the development of
novel approaches to treating both diseases. It is important to
understand the mechanisms by which SARS-CoV-2 invades the central
nervous system (CNS) and the associations and potential shared factors
between COVID-19 and AD.
Keywords: COVID-19, Alzheimer’s disease, correlation, mechanism
of action