Conclusions:
The mechanism by which the virus gains access to the CNS and why patients with AD are at higher risk of virus infection are not well understood.. Although people infected with SARS-CoV-2 frequently display neurological symptoms, multiple manifestations remain unrecognized. First, neurological symptoms are often ignored because the first goal is to combat respiratory symptoms. In addition, clarifying the mechanisms by which SARS-CoV-2 invades and spreads throughout the CNS is important for preventing and ameliorating neurological symptoms. Studies are imperatively needed to clarify the potential mechanisms underlying the elevated susceptibility and mortality rate of AD patients to COVID-19 and discover preventive strategies to minimize the risk of viral infection among patients with AD.