Systems Serology Analysis
To holistically examine the spectrum of antibody signatures obtained via the above mentioned SARS-CoV-2 multiplex array, multivariate analysis techniques were utilised using MATLAB version 9.6 (including machine learning and statistical toolbox) (The MathWorks, Inc., Natick, MA) and Eigenvector PLS toolbox (Eigenvector, Manson, WA). Heatmaps were generated using Morpheus (https://software.broadinstitute.org/morpheus). Prism GraphPad version 9.0.2 (GraphPad Software, San Diego, CA) were used to illustrate final figures and to conduct any univariate analysis. For univariate analysis p value of 0.05 was set as the level for statistical significance, unless otherwise stated.