Systems Serology Analysis
To holistically examine the spectrum of antibody signatures obtained via
the above mentioned SARS-CoV-2 multiplex array, multivariate analysis
techniques were utilised using MATLAB version 9.6 (including machine
learning and statistical toolbox) (The MathWorks, Inc., Natick, MA) and
Eigenvector PLS toolbox (Eigenvector, Manson, WA). Heatmaps were
generated using Morpheus
(https://software.broadinstitute.org/morpheus). Prism GraphPad
version 9.0.2 (GraphPad Software, San Diego, CA) were used to illustrate
final figures and to conduct any univariate analysis. For univariate
analysis p value of 0.05 was set as the level for statistical
significance, unless otherwise stated.