Abstract
Aims: Recurrent pregnancy loss (RPL) is usually defined by two
or more consecutive clinical miscarriages, which causes psychological
trauma for couples. In this study, we aimed to investigate the
predictive role of Fibrinogen to albumin ratio (FAR) in patients with
RPL.
Methods: Pregnant women in their first trimester of pregnancy
were included in the study and divided in to two groups as RPL patients
(n:44) and patients with no previous recurrent miscarriage (n:60) as
control group. Demographical parameters and routine blood parameters
(fibrinogen, D-dimer, fibrinogen to albumin ratio (FAR), neutrophil to
lymphocyte ratio (NLR), platelet count, main platelet volume (MPV), and
red cell distribution width (RDW) values) were compared between the RPL
group and the control group.
Results: The groups were determined to be statistically
different in regards to gravidity and parity (p<0.05). The
difference between the groups was statistically different in regards to
fibrinogen (mg/dl), albumin (g/dl), FAR (%), NLR (%), RDW-coefficient
of variation (CV) (%), RDW-standard deviation (SD) (fL), and platelet
counts (10-3/ uL). However, MPV (fL) and D-dimer
(ug/L) levels were similar in both groups. The receiver operating
characteristic (ROC) curve analysis revealed that the NLR levels were
84.1% sensitive and 75% specific with a cut-off value of 4.27 and the
FAR levels were 79.5% sensitive and 88.3% specific with a cut-off
value of 105.69 for predicting RPL.
Conclusion: Our results indicate that the FAR and NLR levels
seem to be effective parameters for predicting RPL with high sensitivity
and specificity.
Keywords: Recurrent pregnancy loss, FAR, NLR, predictive,
marker
What’s known?
Recurrent pregnancy loss (RPL) is usually defined by two or more
consecutive clinical miscarriages, which causes psychological trauma
for couples.
The prothrombotic conditions affect maternal-fetal circulation and can
impair placental development. These thrombotic processes lead to
venous and/or arterial thrombosis, which can be responsible or
contribute to RPL. Thrombophilia panels including genetic analyzes
were investigated to determine risky populations.