FIGURE 1 Schematic of the microreactor system used to determine
the kinetics of CB nitration
It is worth noting that due to the limited solubility of CB in sulfuric
acid, the mass ratio of sulfuric acid to nitric acid in solution 2 was
kept at approximately 240 to meet the molar ratio of nitric acid to CB.
The large amount of sulfuric acid as a solvent can absorb the reaction
heat. In addition, the reaction conversion was controlled at a low
level, and the thermostat was used to continuously remove the reaction
heat. The calculated increase in the reaction temperature was less than
0.3 °C, which can be completely negligible. The calculation process is
provided in the Supporting Information. It can be considered that the
reaction proceeded under isothermal conditions. Each experiment was
repeated three times. The error bars are marked in figures, and the
final results are the average values of the three measurements.