Aetiology-based preventive treatments and in progress treatments |
Preventive teraphy |
TSC1/TSC2 |
Vigabatrin prior to sz onset |
Jóźwiak
et al 2011 |
|
|
Pyridoxin-dependent epilepsy |
Maternal administration Pyridoxin |
Stockler et al 2010 |
|
Clinical ongoing trial |
SCN1A |
ASO/STK-001 |
https://dravetsyndromenews.com/; the MONARCH trial (NCT04442295) Stoke
Therapeutics |
|
|
nonsense SCN1A mutations |
Ataluren |
https://clinicaltrials.gov/ct2/show/NCT02758626 |
|
|
CDKL5 deficiency |
Ataluren |
https://clinicaltrials.gov/ct2/show/NCT02758626 |
|
In progress (tested only in animal models) |
SCN8A |
ASO |
Lenk et al
2020 |
|
|
SCN1A |
ASO |
Lenk et al 2020 |
|
|
EPM2A/EPM2B |
Gys1-ASO |
Ahonen et al 2021 |