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\begin{document}

\title{Stretch-driven microfluidic chip for nucleic acid detection}



\author[1]{Xiang Li}%
\author[1]{Xiaoyu Zhao}%
\author[1]{Weihao Yang}%
\author[1]{Fei Xu}%
\author[1]{Bailiang Chen}%
\author[1]{Jiwei Peng}%
\author[2]{Jiajun Huang}%
\author[2]{Shengli Mi}%
\affil[1]{Tsinghua University Graduate School at Shengzhen}%
\affil[2]{Tsinghua Shenzhen International Graduate School}%


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  \date{June 17, 2024}


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\begin{abstract}
Molecular diagnosis is an essential means to detect pathogens. The
portable nucleic acid detection chip has excellent prospects in places
where medical resources are scarce, and it is also of research interest
in the field of microfluidic chips. Here, the paper developed a new type
of microfluidic chip for nucleic acid detection where stretching acts as
the driving force. The sample entered the chip by applying capillary
force. The strain valve was opened under the action of tensile force,
and the spring pump generated the power to drive the fluid to flow to
the detection chamber in a specific direction. The detection of COVID-19
was realized on the chip. The RT-LAMP amplification system was adopted
to observe the liquid color in the detection chamber to decide whether
the sample tested positive or negative qualitatively.%
\end{abstract}%



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