Patient related risk factors associated with poor neurocognitive domains (Table 4):
Univariate analysis with multivariate logistic regression was used to assess various risk factors associated with significant neurocognitive deficits (FSIQ<90). The odds of having deficits in neurocognitive function was 5.7 times when a child belonged to lower socioeconomic strata as compared to a child belonging to middle socioeconomic strata (p value=0.004). Parental education had a significant association with adverse neurocognitive deficit with odds being higher when parents were only educated till primary school(4.3 to 4.6 times higher when the father or mother was educated up to primary school respectively). Children whose birth order was 3 or more had a higher probability of having deficits in neurocognitive function(20.1 times higher, p value=0.005). Other factors including gender, age at assessment, age at diagnosis/initiation of treatment and family type did not show any significant association with poorer neurocognitive scores.