Definitions
  1. Treatment completion: Completion of maintenance phase of treatment protocol.
  2. Childhood Cancer Survivor: One who has completed treatment of childhood cancer and is in continued remission for at-least 2 years post treatment completion5,6.
  3. Late Effects: Late effects are defined as any physical or psychological outcome that develops or persists after treatment is completed5,6.
  4. Neurocognitive Deficits: Encompasses the group of disorders in which the primary clinical deficit is in cognitive function and that are acquired rather than developmental7.
Sample size: Based on previous studies4, the prevalence of neurocognitive deficits in ALL survivors was taken as 58.9% and the sample size was calculated with a relative precision of 20% to be 70.
Procedures: Children who met the inclusion criteria, and whose parents/guardians provided a written informed consent, were included in the study. Each participant underwent a basic anthropometric evaluation and medical assessment. Complete demographic details including age, sex, current address, family type, birth order, parental education levels were documented. Socioeconomic stratification was done based on the modified kuppuswamy scale, which is based on education, occupation and income of the head of the family8. Exposure data, including chemotherapy used(with cumulative doses), radiation received and surgical procedures done, was retrieved from the participants medical records stored in their clinic files. Information was collected on a detailed proforma.