Patient related risk factors associated with poor neurocognitive
domains (Table 4):
Univariate analysis with multivariate logistic regression was used to
assess various risk factors associated with significant neurocognitive
deficits (FSIQ<90). The odds of having deficits in
neurocognitive function was 5.7 times when a child belonged to lower
socioeconomic strata as compared to a child belonging to middle
socioeconomic strata (p value=0.004). Parental education had a
significant association with adverse neurocognitive deficit with odds
being higher when parents were only educated till primary school(4.3 to
4.6 times higher when the father or mother was educated up to primary
school respectively). Children whose birth order was 3 or more had a
higher probability of having deficits in neurocognitive function(20.1
times higher, p value=0.005). Other factors including gender, age at
assessment, age at diagnosis/initiation of treatment and family type did
not show any significant association with poorer neurocognitive scores.