Genetics
Patients who experienced neurocognitive decline had an upregulation of
445 genes and a downregulation of 40 genes at POD 4, compared to
patients without NCD. In patients with diabetes, there was an
upregulation of 12 genes and downregulation of 7 genes when compared to
patients without diabetes. In patients with diabetes that experienced
neurocognitive decline there was an upregulation of 277 genes and
downregulation of 220 genes when compared to those patients with
diabetes that had no neurocognitive decline. Within the subset of
patients with NCD, those with diabetes upregulated 121 genes and
downregulated 159 genes when compared to patients who did not have
diabetes. [Figures 2-5]. A list of the top upregulated and
downregulated transcripts for the patients with diabetes,
post-cardiopulmonary bypass, with and without NCD can be found in tables
1-4. Annexin A1 was found to be upregulated 3.14-fold (p= 0.02) above
baseline in the same group of patients.