Conclusion
While hyperglycemia and most inflammatory cytokines do not appear to correlate with increased risk of postoperative neurocognitive dysfunction following cardiac surgery, certain genetic expression trends are apparent. Future directions will need to focus on improving the understanding of factors contributing to genetic expression patterns before and after cardiac surgery, as well as potential ways to modulate that expression and its impact on peri-operative patient care.
Acknowledgements
Funding
Funding for this research was provided by the National Heart, Lung, and Blood Institute (NHLBI). [R01HL46716 (F.W.S.), RO1HL128831-01A1 (F.W.S.]; and 2T32 GM065085-13 (L.A.S.). The funding agencies had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Conflict of Interests/Disclosures:
The authors have no conflicts of interests associated with this work.