Abstract
Background : We aimed to determine the relationship of
ischemia-modified albumin (IMA) with diabetic foot ulcers and its
predictive value in the Wagner classification.
Methods : Our cross-sectional study was conducted in 120
diabetic foot patients and 60 healthy individuals with similar body mass
index and age. Patients with a diabetic foot were classified according
to the Wagner classification. Biochemical parameters, C-reactive protein
(CRP) and IMA levels were measured in all patients and healthy
volunteers. Screening performance characteristics of CRP and IMA were
calculated according to Wagner classes and the presence of
osteomyelitis.
Results: CRP and IMA levels in the patient group were
significantly higher than the control group. The highest IMA levels were
detected in Wagner grade 5. CRP had higher sensitivity and specificity
than IMA in the discrimination of other grades, except for grade 4-5
separation. For Wagner grade 4-5 distinction, IMA had 84.6% sensitivity
and 94.7% specificity.
Conclusion: IMA may play a role in pathogenesis diabetic foot
ulcers and had a higher predictive value in discrimination of the Wagner
grade 4 and 5. In the management of diabetic foot patients, it may be
recommended that IMA is evaluated by clinicians.
Keywords: Diabetic foot, Ischemia modified albumin, Wagner
classification, CRP