A meta-analysis of the prevalence of gestational diabetes in patients
diagnosed with obstetric cholestasis.
Abstract
Objective To determine the prevalence of gestational diabetes in women
with obstetric cholestasis. Design Systematic review and meta-analysis
of data published since 2010. Selection Observation studies with
quantifiable data. Sample A total of 16748 patients with obstetric
cholestasis from 21 studies were included. Methods A pre-defined
protocol with extensive literature search plus other sources to obtain
all possible articles was followed. All articles were evaluated and
included in the study with specified criteria for the risk of bias using
the Newcastle Ottawa Score. A meta-analysis was performed with MOOSE
specifications met. Main Outcome measure Prevalence of gestational
diabetes in the obstetric cholestasis population. Results The prevalence
of gestational diabetes in the obstetric cholestasis population was
13.9% (20 studies analysed). Gestational diabetes was seen more in the
obstetric cholestasis group compared to the non-obstetric group (OR
2.129, 95%CI, 1.697 to 2.670,10 studies). Severe cholestasis has more
gestational diabetes cases (OR 2.168, 95% CI, 1.429 to 3.289, 4
studies) compared to mild cholestasis. Conclusion There is a significant
co-relation of gestational diabetes among the diagnosed obstetric
cholestasis population. With a diagnosis of obstetric cholestasis is
made, it is necessary to test for undiagnosed gestational diabetes
further. This approach may reduce the risk of stillbirth in severe
obstetric cholestasis cases. PROSPERO Registration number CRD42021223886