Limitations and strengths
Our study is limited by the methodological quality of included studies
and by the presence of significant inconsistency and publication bias
that was observed among studies that presented data that were used for
the analysis of investigated primary outcomes. However, we believe that
with the use of sensitivity and meta-regression analysis we were able to
fill the gaps in current research, and underline that the differences in
serum LDH values among the various groups of pregnancy associated
disorders are minimal and do not need further investigation. A
significant limitation of our study is also the lack of a diagnostic and
predictive accuracy analysis that would help determine the actual value
of serum LDH in detecting preeclampsia and differentiating patients at
risk of developing adverse effects (maternal or neonatal).