Conclusion
Compared to non-users, we found combined HRT, but not oestrogen only HRT, to be associated with a reduced risk of all-cause mortality in a large population of healthy women followed up for many years. This information may assist women and their doctors in making decisions around HRT use. This research strengthens the emerging consensus that the benefits of long-term HRT outweigh the harms for most women. However, each woman should make an informed decision about the likely risks and benefits, considering her own clinical condition, concerns and expectations.