Figure 3
Effect of fluconazole, ciprofloxacin and the combination ciprofloxacin/fluconazole on the plasma concentrations of 4-methyl-aminoantipyrine (4-MAA), 4-aminoantyprine (4-AA), 4-formylaminoantipyrine (4-FAA) and 4-acetyl-aminoantipyrine (4-AAA).Healthy male participants were pretreated with placebo (n=12), ciprofloxacin (n=12; 750 mg twice daily for 3 days), fluconazole (n=12, 400 mg loading dose on day -3, followed by 200 mg for day -2 and -1) or the combination ciprofloxacin/fluconazole (n=6; ciprofloxacin and fluconazole as above) before oral administration of 1 g metamizole. 4-MAA, 4-AA, 4-FAA and 4-AAA plasma concentrations were determined by LC-MS/MS. The results are displayed as mean±SEM.