Compliance
Careful review of the pill counting diaries and control of the empty drug blisters indicated that the participants were compliant to the treatment. As displayed in supplementary Figure 2, all participants had residual ciprofloxacin and/or fluconazole plasma concentrations in the morning of the respective study days, also indicating that they were compliant. Surprisingly, when both inhibitors were administered at the same time, the fluconazole plasma concentrations were higher compared to treatment with fluconazole alone, whereas the ciprofloxacin plasma concentrations were in the same range under both conditions.