Effect of the genotype on 4-MAA metabolism
The participants were genotyped for CYP1A2, CYP2B6, CYP2C9, CYP2C19 and CYP2D6 (suppl. Table 3). In Figure 5, the (4-AA+4-AAA+4-FAA)/4-MAA MR at 12 h of the placebo arm is plotted according to the respective genotype of the participants. For CYP2B6 and CYP2D6, there was no visible association between genotype and MR. However, for CYP1A2, 2C9 and 2C19, the MR, which reflects the metabolic activity, correlated with the expected enzymatic activity of the respective genotype.