Figure 4
Effect of fluconazole (FLU), ciprofloxacin (CIP) and the combination fluconazole/ciprofloxacin (CIP/FLU) on the area under the curve (AUC) of the metamizole metabolites.AUCs were calculated based on the plasma concentrations shown in Figure 3 using the linear log trapezoidal method. The graph displays the mean±SEM of the differences to placebo. N=12 male, healthy participants for placebo, fluconazole and ciprofloxacin, and n=6 for the combination fluconazole/ciprofloxacin. Results are displayed as mean±SEM. ***p<0.001 vs. zero and *p<0.05 vs. zero.