Study Drugs
The placebo-controlled study medication was produced under GMP conditions by Dr. Hysek Pharmacy, Biel, Switzerland. In short, Ciprofloxacin Helvepharm© 750 mg tablets and Fluconazole Helvepharm© 200 mg capsules were over-capsuled and placebo capsules were filled with mannitol. The capsules could not be distinguished. To minimize the risk of potential influence of the treatment order, participants were randomly assigned to one of 6 treatment sequences (A-B-C, A-C-B, B-A-C, B-C-A, C-A-B, C-B-A) by computed randomization. The study staff did not have access to the randomization schedule until the final analysis of the plasma samples.
Novalgin© (500 mg metamizole sodium), Ciprofloxacin Helvepharm© (750 mg ciprofloxacin) and Fluconazole Helvepharm© (200 mg fluconazole) were purchased through the University Hospital Pharmacy Basel, Switzerland.