Placebo (n=12)
Fluconazole (n=12)
Ciprofloxacin (n=12)
Fluconazole/Ci-profloxacin (n=6)
4-Methyl-aminoantipyrine (4-MAA) 4-Methyl-aminoantipyrine (4-MAA) 4-Methyl-aminoantipyrine (4-MAA) 4-Methyl-aminoantipyrine (4-MAA) 4-Methyl-aminoantipyrine (4-MAA)
AUC12h (µg/L x h) 75,030 (65,160-86,390) 88,070** (72,910-106,400) 113,200*** (98,930-129,500) 144,300* (124,700-166,900)
Cmax (ng/mL) 15,150 (13,770-16,670) 15,380 (13,740-17,220) 16,420* (14,820-18,190) 17,690 (15,220-20,560)
T1/2 (h)
3.22 (2.84-3.64) 3.69* (3.03-4.49) 3.91*** (3.43-4.45) 6.07* (5.37-6.86)
4-Aminoantipyrine (4-AA) 4-Aminoantipyrine (4-AA) 4-Aminoantipyrine (4-AA) 4-Aminoantipyrine (4-AA) 4-Aminoantipyrine (4-AA)
AUC12h (µg/L x h) 13,680 (9,730-19,240) 12,110* (8,730-16,810) 9,937*** (7,150-13,810) 10,350* (6,717-15,930)
Cmax (ng/mL) 1,621 (1,212-2,167) 1,380* (1,043-1,826) 1,156*** (814-1,642) 1,178* (737-1,884)
4-Formylaminoantipyrine (4-FAA) 4-Formylaminoantipyrine (4-FAA) 4-Formylaminoantipyrine (4-FAA) 4-Formylaminoantipyrine (4-FAA) 4-Formylaminoantipyrine (4-FAA)
AUC12h (µg/L x h) 13,730 (11,290-16,700) 12,560 (10,100-15,610) 9,225*** (7,551-11,270) 6,684* (4,476-9,982)
Cmax (ng/mL) 1,471 (1,222-1,770) 1,350 (1,109-1,645) 1,134*** (946-1,361) 1,031 (831-1,278)
4-Acetylaminoantipyrine (4-AAA) 4-Acetylaminoantipyrine (4-AAA) 4-Acetylaminoantipyrine (4-AAA) 4-Acetylaminoantipyrine (4-AAA) 4-Acetylaminoantipyrine (4-AAA)
AUC12h (µg/L x h) 11,410 (7,742-16,830) 10,460 (6,990-15,640) 7,660*** (5,031-11,660) 5,298* (3,627-7,740)
Cmax (ng/mL) 1,412 (989-2,018) 1,412 (1,012-1,969) 1,358 (968-1,904) 1,322 (1,003-1,742)