Figure 2
In vitro metabolism of 4-methyl-aminoantipyrine (4-MAA) . The N-demethylation of 4-MAA to 4-aminoantipyrine (4-AA) was investigatedin vitro . The reactions were performed in the absence and presence of the specific inhibitors furaphylline (CYP1A2), ticlopidine (CYP2B6), montelukast (CYP2C8), sulfaphenazole (CYP2C9),(1)-N-3-benzylnirvanol (CYP2C19), quinidine (CYP2D6), methylpyrazole (CYP2E1), and ketoconazole (CYP3A4). The results are displayed mean±SEM of 6 independent measurements.