Table 1
Pharmacokinetic parameters of the main metabolites of metamizole . Male, healthy were pretreated with placebo, fluconazole, ciprofloxacin and the combination fluconazole/ciprofloxacin before assessing the metabolism of metamizole. Values are given as geometric mean with the 95% confidence interval in brackets. The elimination half-lives of 4-aminoantipyrine, 4-formylaminoantipyrine and 4-acetylaminoantipyrine could not be calculated. ****p<0.0001, ***p<0.001, **p<0.01, *p<0.05 vs. placebo.