Compliance
Careful review of the pill counting diaries and control of the empty
drug blisters indicated that the participants were compliant to the
treatment. As displayed in supplementary Figure 2, all participants had
residual ciprofloxacin and/or fluconazole plasma concentrations in the
morning of the respective study days, also indicating that they were
compliant. Surprisingly, when both inhibitors were administered at the
same time, the fluconazole plasma concentrations were higher compared to
treatment with fluconazole alone, whereas the ciprofloxacin plasma
concentrations were in the same range under both conditions.