Cytochrome P450 1A2 is the most important enzyme for hepatic metabolism of the metamizole metabolite 4-methylaminoantipyrine
Running head: Metabolism of 4-methylaminoantipyrine in humans
Fabio Bachmann1,2,3, Henriette E. Meyer zu Schwabedissen4, Urs Duthaler1,2,3and Stephan Krähenbühl1,2
1Division of Clinical Pharmacology & Toxicology, University Hospital, 4031 Basel, Switzerland
2Department of Clinical Research, University of Basel, Switzerland
3Department of Biomedicine, University of Basel, Switzerland
4Biopharmacy, Department of Pharmaceutical Sciences, University of Basel, Switzerland
The authors confirm that the Principal Investigator for this paper is Stephan Krähenbühl and that he had direct clinical responsibility for the study participants
Word count (Introduction, Methods, Results and Discussion): 4298
Number of figures and tables: 5 Figures, 1 Table
Key words: metamizole, 4-methylaminantipyrine, 4-formylaminoantipyrine, CYP1A2, CYP2C19