What this study adds:
- Experiments with supersomes revealed CYP1A2 as the major CYP for both
reactions with contributions of CYP2C19 and CYP2D6 to N-demethylation
- These results were confirmed in a clinical study in human healthy
volunteers
- Concomitant treatment with strong CYP1A2 inhibitors may be associated
with dose-dependent adverse reactions of metamizole