Figure 3
Effect of fluconazole, ciprofloxacin and the combination
ciprofloxacin/fluconazole on the plasma concentrations of
4-methyl-aminoantipyrine (4-MAA), 4-aminoantyprine (4-AA),
4-formylaminoantipyrine (4-FAA) and 4-acetyl-aminoantipyrine (4-AAA).Healthy male participants were
pretreated with placebo (n=12), ciprofloxacin (n=12; 750 mg twice daily
for 3 days), fluconazole (n=12, 400 mg loading dose on day -3, followed
by 200 mg for day -2 and -1) or the combination
ciprofloxacin/fluconazole (n=6; ciprofloxacin and fluconazole as above)
before oral administration of 1 g metamizole. 4-MAA, 4-AA, 4-FAA and
4-AAA plasma concentrations were determined by LC-MS/MS. The results are
displayed as mean±SEM.