Table 1
Pharmacokinetic parameters of the main metabolites of metamizole .
Male, healthy were pretreated with placebo, fluconazole, ciprofloxacin
and the combination fluconazole/ciprofloxacin before assessing the
metabolism of metamizole. Values are given as geometric mean with the
95% confidence interval in brackets. The elimination half-lives of
4-aminoantipyrine, 4-formylaminoantipyrine and 4-acetylaminoantipyrine
could not be calculated. ****p<0.0001, ***p<0.001,
**p<0.01, *p<0.05 vs. placebo.