Case Presentation
A 28 years old man, with no systemic disease, presented with recurrent HSV lesion on the right upper eye lid. He received first dose of chadox1 ncov-19 (AZD1222) vaccine on 20th March 2021 during Iran national vaccination program. Besides the common post-vaccination signs and symptoms, two days later, burning pain and blistery skin rashes developed on the right upper eye lid (Figure 1). Ocular examination was done by slit-lamp which showed normal findings. Upper eye lid edema occurred three days later (Figure 2). Along with these findings, patient remembered an infection with HSV following a trauma to the right eye with a hand watch in his childhood. According to the patient, he has experienced periods of cold sore (herpes simplex labialis) after that. Regarding clinical signs and symptoms and the history of the patient, treatment was started based on the diagnosis of recurrent HSV lesion of the upper eye lid. Topical therapy was instructed to the patient including Eye Drop Sulfacetatamide 10% to treat probable bacterial conjectivitis and blepharitis because of severe periorbital edema and Eye Drop Ketotifen and Vitamin A ointment to reduce itching and irritation. 72 hours later, patient reported blurred vision of the right eye, which ocular examinations were normal again. Seven days after the onset of the lesion, signs and symptoms got disappeared. Written informed consent was obtained from the patient for to the publication of this report and clinical images.