Short running title:Increased circulating CRTH2⁺Tregs among patients with asthma

Teerapol Chantveerawong^a, Sasipa Sangkangjanavanich^a,b, Chirawat Chiewchalermsri^a,c, Panitan Pradubpongsa^a, Wat Mitthamsiri^a, Sarawut Jindarat^d, Ming Wang^e, Mübeccel Akdis^f, Milena Sokolowska^f, Cezmi A. Akdis^f, Atik Sangasapaviliya^a, Tadech Boonpiyathad^a,f

^aDivision of Allergy and Clinical Immunology, Department of Medicine, Phramongkutklao Hospital, Bangkok, Thailand

^b Division of Allergy, Immunology and Rheumatology, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand

^cDepartment of Medicine, Panyananthaphikkhu Chonprathan Medical Center, Srinakharinwirot University, Nonthaburi, Thailand

^dDepartment of Pharmacology, Phramongkutklao College of Medicine, Bangkok, Thailand

^eDepartment of Otolaryngology, Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, and the Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, China

^fSwiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, and the Christine Kühne-Center for Allergy Research and Education (CK-CARE), Davos, Switzerland